Chronic Lymphocytic Leukemia
Frequently Asked Questions
Acronyms
General Terminology
Diseases
Treatment Options
Chemotherapies
Blood Stimulating Factors
Frequently-Mentioned BMT Centers
Institutions
 
The acronyms section of the CLL FAQ is included with permission of the copyright holder, Barbara Lackritz.

General Terminology

ALC
absolute lymphocyte count
ANC
absolute neutrophil count
BMB
bone marrow biopsy
BMT
bone marrow transplant (see specifics listed above)
B2M
beta 2 microglobulin
Bx
biopsy
B/P
blood Pressure
CBC
complete blood count
CCDRT
cell culture drug resistance testing
CD
cluster of differentiation
Cnet
Cancernet (where one gets PDQ and Cancer Lit papers)
CR
complete remission
CRN
complete remission with nodular pattern in marrow
CS
clinical Stage
DLI
donor lymphocyte infusion
Dx
diagnosis
ESR
erythrocyte sedimentation rate
EORTC
European Organization for Research and Treatment of Cancer
FISH
Fluorescence In Situ Hybridization. It is a test used to detect chromosome abnormalities in cells and has been used to test lymphocytes in CLL. The results help to predict the prognosis for a particular patient.
GP
General Practitioner: Doctor within NHS (UK)
GVHD
graft versus host disease
GVL
graft versus leukemia or graft versus lymphoma
HCT
hematocrit—the percentage of red blood cells in the blood. A low hematocrit measurement indicates anemia.
HDC
high dose chemotherapy--often used to condition one before a BMT or PBSCT
Hem/Onc
hematologist/oncologist
HGB
hemoglobin
HLA
Human leukocyte antigen test. A special blood test used to match a blood or bone marrow donor to a recipient for transfusion or transplant.
Ig
Immunoglobulin (IgA, IgD, IgE, IgG, IgM)
IV
intravenous—into a vein
LDH
lactate dehydrogenase
Mab or MoAb
monoclonal antibodies (i.e. Campath-1H, Rituxan, Bexxar)
MCV
mean corpuscular volume
MCHC
mean corpuscular hemoglobin concentration
MCH
mean corpuscular hemoglobin
MD
Medical Doctor (USA)
MLUS
monoclonal lymphocytosis of undetermined significance
MRD
minimal residual disease
MUD
matched unrelated donor of bone marrow
NMDP
National Marrow Donor Program --1-800-526-7809
NR
nodular remission (nodules of cancer cells remain in the marrow, but there are less than 10% cancer cells throughout)
OR
overall remission
PCP
primary care physician
PCR
polymerase chain reaction
PDQ
physicians data query
PHN
postherpetic neuralgia
PR
partial remission
RBC
red blood count
RDW
red cell distribution width
RX
prescribed medication
SMIG
surface membrane immunoglobulin
SWOG
Southwest Oncology Group
TBI
Total body irradiation
TRM
treatment-related mortality
WBC
white blood count WBC/HPF white blood cells counted per high powered field WD well differentiated WW watch and wait (also called, watch and worry)
XRT
external radiation therapy

Diseases

AA
aplastic anemia
AIHA
autoimmune hemolytic anemia
ALL
acute lymphocytic leukemia (+3 subtypes according to morphology. L1-L3 and subtypes according to phenotype: T, pre-B, pre-pre-B, B)
AML
acute myelogeneous leukemia (+8 subtypes MO-M6)
AMM
agnogenic myeloid metaplasia
AMML
acute myelogeneous leukemia
ANLL
acute non-lymphocytic leukemia (same as AML above)
APL
acute prolymphocytic leukemia
APML
acute promyelocytic leukemia
BCP-ALL B-cell
precursor acute lymphoblastic leukemia
CLL
chronic lymphocytic leukemia
CML
chronic myeloid leukemia (each has subtypes)
CMML
chronic myelomonocytic leukemia CNSL central nervous system lymphoma
ET
essential thrombocythemia
HCL
hairy cell leukemia HD Hodgkins lymphoma (4 subtypes)
ITP
idiopathic thrombocytopenic purpura
MCL
mantle cell lymphoma
MBL
monoclonal B-Cell lymphocytosis
MDS
myelodysplastic syndrome (4 subtypes)
MF
mycosis fungoides (cutaneous T-cell lymphoma)
MM
multiple myeloma
MPD
myeloproliferative disorders
NHL
non-Hodgkins lymphoma (many subtypes)
PLL
prolymphocytic leukemia
PV
polycythemia vera
SLL
small lymphocytic lymphoma
SLVL
splenic lymphoma with villous lymphocytes
WM
Waldenstrom's Macroglobulinemia

Treatment Options

ABMT
autologous bone marrow transplant—your own marrow
BMT
allogeneic bone marrow transplant—someone else's marrow
PBPC
peripheral blood progenitor cell transplant (which is becoming the new standard term)
PBSCT
peripheral blood stem cell transplant
PBSCR
peripheral blood stem cell rescue
PSCT or PSCR
the same as above without the word "blood."
SBMT
syngeneic bone marrow transplant—identical twin's marrow

Chemotherapies

ABVD
doxorubicin, vinblastine, bleomycin, DTIC
ACOB
doxorubicin, cyclophosphamide, vincristine, bleomycin ARA-C cytarabine
ATRA
all-trans retinoic acid, or Vesanoid
BACOP
bleomycin, doxorubicin, cyclophosphamide, vincristine, prednisone
BEAM
busulfan, etoposid, ara-c, melphalan
BLEO
bleomycin
2CdA
2-chlorodeoxyadenosine (Generic name = cladribine)
C-MOPP
cyclophosphamide, oncovin, procarbazine, prednisone
CCNU
(1-2-chloroethyl)-3-cyclohexyl-1-nitrosourea)
CHOD
cyclophosphamide, doxorubicin, vincristine, dexamethasone
CHOP
cyclophosphamide, adriamycin, vincristine, prednisone
CHOP-BLEO
cyclophosphamide, doxorubicin, vincristine, prednisone and bleomycin
CMF
cyclophosphamide, methotrexate, fluorouacil
COP
cyclophosphamide, oncovin, prednisone
COPP
CCNU, vincristine,procarbazine, prednisone
CyA
cyclosporin A
CVP
cyclophosphamide, vincristine, prednisone
DCF
2-deoxycoformycin (pentostatin)
DTIC
dacarbazine, 5-(3,3-dimethyl-1-triazino)imidazole-4-carboxamide
EPOCH
etopside, prednisone, vincristine, cyclophosphamide (cytoxan), adriamycin
ESHAP
etopside (VP-16), methylprednisolone (SOL), cytarabine (AraC), cisplatin (CDDP) and prednisone (Pred).
FAC
fluorouacil, adriamycin, cyclophosphamide
FCR
fludarabine, cyclophosphamide, rituxan
Flu
fludarabine (Fludara)
IFN
Interferon (comes in alpha2a, alpha 2b, human leukocyte, and beta--Another one "concensus" is still in trials)
IL
Interleuken
mBACOD
methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone
MOPP
nitrogen mustard, vincristine, procarbazine, prednisone
MTX or M
methotrexate
proMACE
prednisone, methotrexate with leukovorin rescue, doxorubicin, cyclophosphamide, etoposide (VP-16)
RFC
rituximab, fludarabine, cyclophosphamide

Blood Stimulating Factors

EPOIETIN
erythropoietin (Epogen)-- is used to stimulate red cell growth.
G-CSF
granulocyte colony stimulating factor (Neupogen)- stimulates growth of white cells .
GM-CSF
granulocyte macrophage - colony stimulating factor (sargramostim)
NEUMEGA
platelet stimulating factor
TPOIETIN
thrombopoietin - (platelet stimulating factor)

Frequently-Mentioned BMT Centers

ACRC
Arkansas Cancer Research Center
Brigham
Brigham and Women's Hospital, Boston, MA
DFCI
Dana Farber Cancer Institute, Boston, MA
FHCRC or the Hutch
Fred Hutchinson Cancer Research Center, Seattle, WA
JH
Johns Hopkins Medical Center, Baltimore, MD
MDACC
MD Anderson Cancer Center, Houston, TX
MSK or MSKCC
Memorial Sloan-Kettering Cancer Center, NYC, NY
NCI
National Cancer Institute, Bethesda, MD
Roswell
Roswell Park Cancer Center in Buffalo, NY
Strong
Strong Memorial Cancer Center at Univ. of Rochester, NY
see: http://www.acor.org/leukemia/canctrs.html for others

Institutions

ACOR
Association of Cancer Online Resources
CIS
cancer information service (of NCI) 1-800-4-CANCER
CLL Found
CLL Foundation to raise funds for CLL Research
ECOG
Eastern Cooperative Oncology Group
FDA
Food and Drug Administration (USA)
NCI
National Cancer Institute (USA)
NIH
National Institutes of Health
LRF
Leukaemia Research Fund (UK)
LSA
Leukemia Society of America (USA)
NHS
National Health Service (UK)